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Neurofilament Light Chain And Voice Acoustic Analyses In Dementia Diagnosis

RECRUITINGSponsored by Monash University
Actively Recruiting
SponsorMonash University
Started2021-08-01
Est. completion2025-12
Eligibility
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06339190

Summary

This cohort study aims to determine if a blood test can aid with diagnosing dementia in anyone presenting with cognitive complaints to a single healthcare network. The investigators will measure levels of a brain protein, Neurofilament light chain (Nfl), and assess changes in language using speech tests. Participants will have a single blood test and speech test, and will be followed up at 12-months to complete questionnaires and cognitive scales over the phone. The speech test will also be completed again at 12-months. Individuals at risk of a Fronto-temporal dementia syndrome will be eligible to complete optional genetic testing involving an 'at home' saliva sample.

Eligibility

Healthy volunteers accepted
Inclusion Criteria:

* All patients presenting to Eastern Health services with a cognitive complaint or potential neurodegenerative disorder

Exclusion Criteria:

* Prognosis \<12 months
* No cognitive complaint
* Patients not involved within the single healthcare network

Conditions3

Alzheimer's DiseaseDementiaNeurodegenerative Diseases

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