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Early Detection of Advanced Adenomas and Colorectal Cancer

RECRUITINGSponsored by City of Hope Medical Center
Actively Recruiting
SponsorCity of Hope Medical Center
Started2020-03-15
Est. completion2026-06-18
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations2 sites

Summary

This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* All individuals included in the study need to have had a colonoscopy at the time of blood sampling.
* Received standard diagnostic and staging (as necessary) procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment.
* Received standard pathological and endoscopic diagnosis and assessment for cohort assignment.

Exclusion Criteria:

* Hereditary colorectal cancer syndromes (identified through genetic testing).
* Inflammatory bowel diseases.
* Lack of written informed consent.

Conditions21

CancerColorectal AdenocarcinomaColorectal Adenocarcinoma Metastatic in the LiverColorectal Adenoma With Mild DysplasiaColorectal Adenoma With Moderate DysplasiaColorectal Adenoma With Severe DysplasiaColorectal Adenoma and Carcinoma 1Colorectal Adenomatous PolypColorectal CancerColorectal Cancer Stage I

Locations2 sites

City of Hope Medical Center
Monrovia, California, 91016
Ajay Goel, PhD626-218-3452AJGOEL@COH.ORG
University of California San Diego
San Diego, California, 92093
C Richard Boland, MD, PhD

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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