Noninvasive Evaluation of Fetal Hyperinsulinemia With Ultrasound Radiomics

Summary

The goal of this observational study is to compare fetal liver ultrasound radiomics between pregnancies complicated by type 1 diabetes and healthy controls. The main questions it aims to answer are: * Are fetal liver ultrasound radiomic features reproducible? * Does fetal liver ultrasound radiomics differ between pregnancies complicated by type 1 diabetes and healthy controls? Participants will undergo ultrasound examination to collect ultrasound data for the analyses.

Eligibility

Inclusion Criteria:

* Age between 18-45 years
* Capable to give an informed consent
* Singleton pregnancy
* Planning to deliver in Turku University Hospital
* Maternal BMI \< 40
* Gestational age should be confirmed by first trimester ultrasound
* Normal oral glucose tolerance test (OGTT) at 24-28 gestational weeks in controls

Exclusion Criteria:

* Major fetal chromosomal, genetic, or structural anomaly
* Fetal growth restriction, or birth weight \< 10th centile
* Birth weight \> 90th centile or polyhydramnios in the controls
* Non-reassuring fetal status requiring immediate treatment, or intrauterine fetal demise
* Verified fetal infection (e.g. cytomegalovirus, toxoplasma, hepatitis B and C), excluding bacterial infection due to intrapartum chorioamnionitis
* Placenta accreta spectrum disorder
* Major maternal medical condition requiring systemic pharmacological treatment, other than non-severe hypertension, hypothyroidism, asthma, mild psychiatric disorders, etc.
* Alcohol or tobacco use, or substance abuse in pregnancy

Conditions4

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