Impact of Eccentric Training in Hypoxia With Creatine on Metabolic Control and VO2max in Patients With Type 1 Diabetes

Summary

Exercise plays an important role in treatment of diabetes. In recent years exercise training in normobaric hypoxia is used in training programs for athletes and in rehabilitation and also commercially. The aim of the study is to assess the impact of eccentric training conducted in conditions of normobaric hypoxia or normoxia and creatine supplementation on metabolic control: profile and stability of glucose concentration, HbA1c value, hypoglycemia and insulin demand, as well as the level of muscle strength, VO2max and anthropometric parameters

Eligibility

Inclusion Criteria:

* type 1 diabetes of at least 10 years duration,
* low physical activity,
* BMI:20-31 kg/m2,
* treated with multiple insulin injections (at least 4 daily) or insulin pump (continuous subcutaneous insulin infusion \[CSII\]),
* negative ECG exercise test,
* HbA1c ≤ 8,0%,
* high knowledge about functional insulin therapy, carbohydrate counting and diabetes management during exercise,
* experience in use of FreeStyleLibre2 (Flash Glucose Monitoring System, Abbott),
* Informed consent to participate in research signed by enrolled subjects

Exclusion Criteria:

* HbA1c \> 8,0%,
* advanced complications of diabetes \[pre-proliferative or proliferative retinopathy, and previous laser therapy, microalbuminuria or overt nephropathy, autonomic neuropathy (including lack of elevated heart rate during physical activity)\],
* patients physically active (regular physical activities more than once a week),
* positive ECG exercise test,
* history of cardiovascular event or coronary heart disease

Conditions2

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