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Hepatocellular Carcinoma Liver Organoids

RECRUITINGN/ASponsored by Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Actively Recruiting
PhaseN/A
SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS
Started2023-06-15
Est. completion2025-03
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06355700

Summary

The goal of this interventional study is to create hepatocellular carcinoma organoids from liver bioptic samples of individuals with hepatocellular carcinoma. The main questions it aims to answer are: * the feasibility of hepatocellular carcinoma organoids integrated with host gut microbiota and peripheral blood mononuclear cells * the molecular pattern of the organoid tumor microenvironment * the in vitro therapeutic response of hepatocellular carcinoma organoids

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Ability to express informed consent
* Patients ≥ 18 years of age
* Radiological diagnosis of hepatocellular carcinoma (HCC)

Exclusion Criteria:

* Patients \<18 years of age
* Contraindications for liver biopsy: ascites, platelet count \<50.000, International Normalized Ratio (INR) \>1.7
* Active viral infection
* Refusal to give informed consent for the study

Conditions4

CancerHepatocellular CarcinomaLiver CancerLiver Disease

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