Effect of High Intensity Exercise Rehabilitation on Liver Function and Insulin Sensitivity in Patients With MASLD

Summary

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease worldwide, and is associated with obesity and the metabolic syndrome. Physical activity and lifestyle interventions are among the most recommended treatments for individuals with MASLD. In this RCT, we will evaluate the effect of combined exercise training "strength and aerobic training" versus "strength and high intensity training (HIIT)". The main outcome parameter is the severity of liver steatosis. Patients will be recruited at the fatty liver clinic of the UZ Gent.

Eligibility

Inclusion Criteria:

* Diagnosed with MASLD by ultrasound, CAP and/or biopsy
* Age between 18 and 75 years old
* No significant liver fibrosis (Fibroscan \< 7.5 kPa; if it is between \>7.5 and \<10, there must be absence of liver fibrosis in the biopsy)

Exclusion Criteria:

* Presence of other liver diseases that may contribute to the clinical presentation in the patient
* Severe cardiovascular, orthopedic, physical or other illnesses that make it impossible to participate in the study's exercise rehabilitation program or where safety cannot be guaranteed
* Pregnancy
* Pharmacological treatment that directly affects MASLD (e.g. GLP-1 analogues)
* A change in medication in the last three months before the study that affects metabolic disease stability

Conditions3

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