A Multi-omics Study of "Healthy" Premature CAD Patients

Summary

The goal of this multi-center observational clinical trial is to investigate the genetic risk factors of patients with premature CAD and none traditional CAD risk factors through a multi-omics approach. The main questions it aims to answer are: * Genetic risk factors \& metabolic fingerprints of patients with premature CAD and none traditional CAD risk factors remain unknown. * How to optimize current primary prevention strategy for this rare CAD subgroup？

Eligibility

Inclusion Criteria for cases:

1. In-patients from cardiology department of either following 3 hospitals: a) The First Affiliated Hospital of Nanjing Medical University; b) Qilu Hospital of Shandong University; c) The Second Affiliated Hospital Zhejiang University School of Medicine
2. Confirmed diagnosis of Obstructive CAD (≥50% diameter stenosis in a major epicardial vessel) through coronary angiography
3. Age of the patient when Obstructive CAD was for the first time diagnosed should be no more than 45 years old for the male and 55 years old for the female.

Inclusion Criteria for controls:

1. In-patients from cardiology department of either following 3 hospitals: a) The First Affiliated Hospital of Nanjing Medical University; b) Qilu Hospital of Shandong University; c) The Second Affiliated Hospital Zhejiang University School of Medicine
2. Coronary artery stenosis was ruled out through either coronary angiography or coronary CTA.

Exclusion Criteria for both cases and controls:

1. Patients with hypertension (grade 1-3)
2. Patients with type 1 or type 2 diabetes mellitus
3. BMI \>28.0 Kg/m\^2
4. Patients with non-ideal blood lipids level on admission(defined as either LDL-C≥2.6mmol/L OR non-HDL cholesterol≥3.4mmol/L OR Lipoprotein(a) ≥300mg/L)
5. Smoker (Smoking for more than 6 consecutive or cumulative months in a lifetime, whether quit smoking or not)
6. Patients with hyperuricemia or gout
7. eGFR\<60 ml/min·1.73m\^2
8. Patients with structural heart diseases, inherited cardiomyopathies \& arrhythmias
9. Other reasons a participant considered unsuitable for inclusion by researchers.

Conditions2

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