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Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR

RECRUITINGPhase 3Sponsored by Wake Forest University Health Sciences
Actively Recruiting
PhasePhase 3
SponsorWake Forest University Health Sciences
Started2024-10-07
Est. completion2026-12
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06376916

Summary

The purpose of this prospective, randomized, double-blinded study is to further evaluate the safety and efficacy of varying doses of intravenous magnesium in the treatment of AFF RVR.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Age \> 18 years or older
* Able to provide informed consent
* Primary diagnosis AFF RVR greater than or equal to 120 bpm
* Diltiazem as rate control agent
* English speaking

Exclusion Criteria:

* Hemodynamically unstable patients (SBP \<90, MAP \<65)
* Impaired consciousness
* End stage renal disease on hemodialysis or peritoneal dialysis
* Acute heart failure exacerbation based on clinical diagnosis, physician exam, bedside echo, and/or additional imaging
* Patient in AFF RVR that is highly suspected to be a compensatory mechanism for an alternative clinical diagnosis
* Rhythms other than AF, such as sick sinus syndrome or wide-complex ventricular response
* Acute myocardial infarction
* Pregnancy defined as a positive urine HCG (human chorionic gonadotropin)
* Contraindications to magnesium sulfate (including myasthenia gravis)
* Allergy or sensitivity to any study drugs
* Previously enrolled in this trial during a different patient encounter
* Withdrew from study

Conditions4

Atrial FibrillationAtrial Flutter With Rapid Ventricular ResponseHeart DiseaseTachycardia Atrial

Locations1 site

Advocate Christ Medical Center Emergency Department (ACMC ED)
Oak Lawn, Illinois, 60453
Marc McDowell, PharmD708-684-6230marc.mcdowell@aah.org

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