PD-L1 Specific [68Ga]Ga-THP-PDL1-3 Probe for PET Imaging in Solid Tumors

Summary

To utilize the \[68Ga\]Ga-THP-PDL1-3 molecular probe to non-invasively detect PD-L1 expression in primary and metastatic lesions of patients with solid tumors. Furthermore, to assess the heterogeneity of PD-L1 expression within the same lesion and across different lesions, and to observe changes in PD-L1 expression during the course of treatment. This approach aims to facilitate patient screening, therapeutic monitoring, and early warning of drug resistance and/or recurrence or metastasis in the treatment of solid tumors with high PD-L1 expression, ultimately enabling personalized targeted therapy in oncology.

Eligibility

Inclusion Criteria:

1. Age 18-70 years, ECOG score 0 or 1;
2. Patients with solid tumors;
3. Presence of measurable lesions on imaging examinations;
4. Expected survival ≥12 weeks.

Exclusion Criteria:

1. Severe hepatic or renal dysfunction;
2. Women who are planning pregnancy, pregnant, or breastfeeding;
3. Unable to remain in supine position for 30 minutes;
4. Refusal to participate in this clinical study;
5. Diagnosis of claustrophobia or other psychiatric disorders;
6. Other conditions deemed by the investigator as inappropriate for participation in the trial.

Conditions2

Interventions2

Related trials

• 68Ga-FAPI-RGD PET/CT Imaging in the Lung Cancer Patients — Peking Union Medical College Hospital
• 68Ga-RM26-RGD PET/CT Imaging in the GRPR and αvβ3 Positive Tumor Patients — Peking Union Medical College Hospital
• A Molecular Probe Targeting BCMA for the Clinical Diagnosis of Multiple Myeloma — Peking University First Hospital
• CD147 Targeting Nanobody Probe for PET Imaging in Solid Tumors — Hua Zhu
• CLDN18.2 Targeting Nanobody Probe for PET Imaging in Solid Tumors — Peking University Cancer Hospital & Institute
• Dosimetry and Preliminary Clinical Application Study of a Novel Probe Targeting CD73 — First Affiliated Hospital of Fujian Medical University
• Lung Nodule Detection Using Ultra-long FOV PET/CT — University Medical Center Groningen
• Nectin-4 Specific LMW PET Probe Imaging in Urothelial Carcinoma — Peking University Cancer Hospital & Institute

Browse More Trials