Electroencephalography-based Precise Repetitive Transcranial Magnetic Stimulation Treatment

Summary

This study will focus on the hypothesis that repetitive transcranial magnetic stimulation (TMS) based on EEG personalized modulation may be more effective in promoting symptomatic relief of major depressive disorder (MDD), and will rely on the platform of neuroimaging and function brain imaging of Shanghai Mental Health Center (SMHC), an authoritative institution in the field of mental health. We will eventually facilitate optimization of physical therapy for major depressive disorder (MDD).

Eligibility

Inclusion Criteria:

* The diagnosis of participants should be made in accordance to the diagnostic criteria described for Major Depressive Disorder (MDD) of the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-V).
* be willing to receive neuromodulation therapy and sign the written informed consent
* an age of 16-65 years
* The patient's medication regimen is based on only one antidepressant, and the medication regimen is not adjusted as much as possible during the treatment period.
* Having a total score of not less than 20 on the Hamilton Depression Rating Scale (HAMD-24).
* sufficient hearing or reading ability

Exclusion Criteria:

* History of electroconvulsive therapy (ECT)
* Presence of metallic foreign bodies near the stimulation coil or stimulation scalp, e.g., intracranial metal implants, cochlear implants, built-in pulse generators (brain pacemakers, cardiac pacemakers)
* Epilepsy
* Pregnancy
* History of head injury
* Mental disorders such as schizophrenia, bipolar disorder, schizoid personality disorder, alcohol/drug abuse or dependence, etc.
* Serious physical illnesses
* Taking medication that lowers the seizure threshold
* Participating in any clinical trial within 30 days before the baseline
* Other situations judged by the investigators not to be suitable for the clinical trial

Conditions2

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