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SPECT Imaging for Pharmacokinetics and dosimEtry Towards TREATment Optimization

RECRUITINGSponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Actively Recruiting
SponsorSidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Started2025-02-03
Est. completion2028-11
Eligibility
Age18 Years – 100 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06389097

Summary

The investigators will study SPECT imaging of radiopharmaceutical therapies given as standard of care or as part of other compatible research protocols. The goal is to validate the quantitative SPECT image reconstruction methods developed in this proposal, and to investigate the relation between dosimetry calculated from SPECT images and the outcomes. Patients will be recruited for SPECT/CT imaging during treatment. This is an observational study no additional new drugs or activities will be administrated. The investigators will perform SPECT imaging on a total of 80 patients (\~20 each from year 2 to year 5). Each participant will be imaged 3 times after the first and last cycles of planned radiopharmaceutical therapy.

Eligibility

Age: 18 Years – 100 YearsHealthy volunteers accepted
Inclusion Criteria:

* Cohort A: Patients with advanced prostate cancer planning to undergo treatment with Radium-223
* Cohort B: Patients with advanced cancer undergoing treatment with 177Lu-DOTATATE or 177Lu-PSMA-617

  \*\*Eligible patients may be planning to undergo these treatments as part of standard of care or as part of another research protocol
* Age \> 18 years
* Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2
* Histologic confirmation of malignancy

Exclusion Criteria:

* Patient is participating in another research protocol that does not allow participation in this imaging protocol or that has schedule of procedures that would not be compatible with this protocol.
* Patient unable to tolerate SPECT scan time, scan frequency, or position.

Conditions3

Advanced CancerCancerProstate Cancer

Locations1 site

Johns Hopkins University
Baltimore, Maryland, 21287

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