PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest

Summary

Brain injury is the main cause of death and disability for patients surviving cardiac arrest resuscitation and seizures are diagnosed in up to a third of these patients. The investigators are proposing a pilot randomized placebo-controlled clinical trial to evaluate the safety and feasibility of perampanel use for post-cardiac arrest status epilepticus (PCARSE) prevention after cardiac arrest.

Eligibility

Inclusion Criteria:

* Age ≥18 years old
* Non-traumatic, out-of-hospital cardiac arrest
* Comatose on admission - defined as not following commands
* Return of spontaneous circulation (ROSC) within less than 45 minutes from the time of cardiac arrest (defined as the time of 911 or EMS (emergency medical services) witnessed arrest)
* Admission to the intensive care unit at Zuckerberg San Francisco General Hospital

Exclusion Criteria:

* Acute cerebral hemorrhage or infarction
* Pregnancy
* Prisoner
* Severe kidney function impairment with creatinine clearance inferior to 30 ml/min
* Severe liver impairment with liver function tests five times above the upper limit of normal
* Electrographic or electroclinical seizures diagnosis using American Clinical Neurophysiology criteria confirmed by an epileptologist after cardiac arrest

Conditions4

Locations1 site

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