Prehabilitation in Oncological Patients Undergoing Major Gastrointestinal Surgery (PROGRESS)

Summary

The importance of postoperative rehabilitation on physical performance and recovery is well-recognized. However, the preoperative period constitutes a unique opportunity to address comorbidities and modifiable risk factors, improve functional capacity and address deficiencies in physiologic reserve, which might otherwise preclude surgery or significantly impede recovery. Therefore, the aim of this study is to evaluate the efficacy of a multimodal program of prehabilitation in patients undergoing major oncological gastrointestinal surgery. The hypothesis is that severe post-operative complications within 30 days will be reduced in the treatment group compared to the control group.

Eligibility

Inclusion Criteria:

* All adult patients (age \> 18 years) scheduled for elective gastrointestinal surgery for cancer.
* Signed informed consent

Exclusion Criteria:

Co-morbid medical, physical, and mental conditions interfering with the ability to complete study procedures, such as:

* acute or unstable cardio-respiratory conditions (e.g., unstable angina or symptomatic severe aortic stenosis)
* severe/end-stage organ diseases (e.g., cardiac failure NYHA functional classes III-IV, COPD FEV1 \<50% pred, end-stage kidney or liver disease);
* American Society of Anesthesiologists (ASA) physical status classes 4-5.
* disabling orthopedic and neuromuscular disease.
* psychosis, dementia;
* symptomatic anemia.
* Pregnancy

Conditions3

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