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Left Atrial Appendage Arrhythmogenic and Thrombogenic Substrate

RECRUITINGN/ASponsored by University Hospital Bispebjerg and Frederiksberg
Actively Recruiting
PhaseN/A
SponsorUniversity Hospital Bispebjerg and Frederiksberg
Started2024-08-01
Est. completion2035-12-31
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06405750

Summary

The purpose of the project is to elucidate whether it is possible to identify which patients are at risk of forming blood clots that can cause stroke based on analysis of the electrocardiogram. In connection with the operation, the small pouch known as the auricle of the heart is closed, which can be completely removed after closing. This procedure is common in patients with atrial fibrillation to protect the brain from stroke. In the project, all patients will have this auricle closed if they agree to participate in the project. After closure, the auricle is usually discarded. We will analyze the blood and the auricle tissue taken (if available) in connection with the operation itself, together with the analysis of the electrocardiogram recorded before the planned heart operation.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* signed informed consent AND
* planned any open-heart surgery:

  * CABG
  * valve repair or replacement
  * aorta surgery
  * any combination of the above

Exclusion Criteria:

* current endocarditis
* follow-up not possible

Conditions3

Atrial FibrillationHeart DiseaseStroke

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