Risk Assessment Evaluation for Identifying Participants at High Risk for Stomach Cancer

Summary

This clinical trial evaluates the usefulness of various risk assessment tests, including Helicobacter pylori (H. pylori) breath testing, questionnaires, and endoscopies for identifying participants at high risk for stomach cancer. H. pylori is a bacteria that causes stomach inflammation and ulcers in the stomach. People with H. pylori infections may be more likely to develop cancer in the stomach. H. pylori breath testing can help identify the presence of H. pylori infection in a participant and help identify if the participant may be at a higher risk of developing stomach cancer. An endoscopy uses a thin, flexible lighted tube that is inserted inside the esophagus, stomach, and first part of the small intestine. This allows the doctor to see and look for abnormal areas that may need to be biopsied. Risk assessment including H. pylori evaluation, questionnaires, and endoscopies may help identify participants at high risk for stomach cancer and may be a useful screening tool for earlier stomach cancer diagnosis.

Eligibility

Inclusion Criteria:

* Documented informed consent of the participant and/or legally authorized representative

  * Assent, when appropriate, will be obtained per institutional guidelines
* Age: ≥ 40 years to ≤ 80 years
* Identify as a racial minority either Asian, Hispanic, or Black American
* Willingness to:

  * Provide blood samples and undergo upper endoscopy

Exclusion Criteria:

* Identify as Non-Hispanic White
* History of gastric cancer
* Known premalignant lesions of the stomach
* History of upper endoscopy within 2 years
* Women of childbearing potential: Pregnant/ nursing
* An employee who is under the direct/indirect supervision of the principal investigator (PI)/a coinvestigator/the study manager
* A direct study team member

Conditions2

Locations1 site

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