Effectiveness of MST Versus ECT for Major Depressive Episode

Summary

Despite advancements in Magnetic Seizure Therapy (MST) and Electroconvulsive Therapy (ECT) for Major Depressive Disorder (MDD), there remains a need for further research to replicate clinical outcomes and understand the therapeutic targets of these treatments. This study aims to address these gaps through a double-blinded, randomized, non-inferiority investigation comparing the efficacy, tolerability, cognitive adverse effects, and neurophysiological biomarkers of MST and bilateral ECT in patients with MDD.

Eligibility

Inclusion Criteria:

* Participants must meet the diagnostic criteria for MDD as outlined in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5).
* Participants must have a baseline score of 18 or higher on the 24-item Hamilton Depression Rating Scale (HDRS-24).
* During the trial's treatment period, participants must be using a single antidepressant medication at a stable dose.
* Participants must be between the ages of 18 and 65 years.
* Informed consent from both parents and legal guardians is required.

Exclusion Criteria:

* Individuals with current or history of organic brain disorders or neurological disorders will be excluded from the study.
* Participants with a Wechsler Abbreviated Scale of Intelligence (WASI) score of less than 70 will be excluded.
* Individuals currently taking antiepileptic drugs, benzodiazepines, or other medications that may affect seizure activity will be excluded from the study.
* Those with exposure to ECT, modified ECT, MST, transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), or other neurostimulation treatments in last 6 months will be excluded.
* Individuals with cochlear implants, cardiac pacemakers, implanted devices, or metal in the brain will be excluded from participation.
* Pregnant or lactating individuals will be excluded from the study.
* Individuals currently participating in another concurrent clinical trial will not be eligible for inclusion.
* Participants who refuse to provide informed consent to participate in the trial will be excluded.
* Other circumstances deemed unsuitable for participation by researchers will result in exclusion.

Conditions2

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