Research on the Brain Mechanism of taVNS in Regulating PD Motor Symptoms

Summary

This study is a double blind comparative study exploring the neural underpinnings of taVNS modulating PD motor deficits. We hypothesize that taVNS might improve PD motor deficits by regulating the balance between excitation and inhibition in the primary motor cortex.

Eligibility

Inclusion Criteria:

* (1) had a diagnosis of idiopathic PD according to the Movement Disorder Society Clinical Diagnostic Criteria for PD and ON-medication Hoehn and Yahr (H\&Y) stage ≤2,
* (2) had stable pharmacotherapy for PD at least one month prior to the study,
* (3) were aged between 40 and 80,
* (4) signed written informed consent,
* (5) can cooperate with the testing and taVNS treatment.

Exclusion Criteria:

* (1) with cognitive impairment, according to Montreal Cognitive Assessment (MOCA) \< 24;
* (2) with severe tremor or levodopa-induced dyskinesia;
* (3) with current intake of anticholinergics or any drugs that could induce cerebral functional change;
* (4) with taVNS contraindications;
* (5) received VNS treatment during the past six month;
* (6) with concomitant severe neurologic, renal, cardiovascular, or hepatic disease.

Conditions2

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