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The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)

RECRUITINGSponsored by Massachusetts General Hospital
Actively Recruiting
SponsorMassachusetts General Hospital
Started2024-04-15
Est. completion2026-04-14
Eligibility
Age18 Years – 99 Years
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06412172

Summary

Recurrent respiratory papillomatosis (RRP) is an orphan disease that affects approximately 20,000 people in the United States and is caused by infection with human papillomavirus (HPV) types 6 and 11. Since RRP is an orphan disease, it is an understudied disease entity with correspondingly few treatment options. The investigators hypothesize that by understanding the biology of RRP and the failed host immune responses against HPV, novel and rational therapies can be developed. This study will examine the genetic and immunologic alterations found in these rare tumors and distant metastatic involved sites (such as the lung) in patients diagnosed with RRP.

Eligibility

Age: 18 Years – 99 YearsHealthy volunteers accepted
Inclusion Criteria:

* History of HPV-associated Recurrent Respiratory Papillomatosis
* Has pulmonary lesions

Exclusion Criteria:

* None

Conditions4

CancerLung CancerPulmonary NeoplasmRecurrent Respiratory Papillomatosis

Locations1 site

Yale School of Medicine
New Haven, Connecticut, 06520
Sara Pai, MD, PhD

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