VIsualization of Coronary Artery Disease for Modification of RISK Factors

Summary

The VICAD-RISK study assesses if visualization of coronary CT angiography (CTA) images in participants with non-obstructive coronary artery disease will improve LDL lowering, reduce reporting of side effects by cholesterol lowering medications, and modify the coronary artery disease phenotype over 12 months.

Eligibility

Inclusion Criteria:

* New diagnosis of nonobstructive coronary artery disease
* No known coronary artery disease (no previous coronary revascularization)
* CAD-Rads score 1-3
* LDL cholesterol \> 2.0 mmol/l
* Life expectancy \>3 years
* Signed informed consent

Exclusion Criteria:

* Post CTA test indication for invasive coronary angiography
* Non-evaluable CTA exam
* Obstructive coronary disease (One or more coronary stenosis ≥70%, left main \>40%)
* Ongoing lipid lowering medical treatment (Patients already on lipid lowering medical therapy can be included if the treatment was initiated \<3 months before the time of the CTA test)
* BMI \>40
* Renal insufficiency (eGFR \<40 ml/min)
* Allergy to iodinated contrast media
* Contraindications to statins (Active liver disease Child-Pugh A, B and C, excessive alcohol consumption)
* Participation in a cardiac rehabilitation or lifestyle modification program
* Pregnancy

Conditions3

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