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Exploration of Mechanisms for Weaning Failure

RECRUITINGSponsored by The First Affiliated Hospital of Guangzhou Medical University
Actively Recruiting
SponsorThe First Affiliated Hospital of Guangzhou Medical University
Started2024-07-09
Est. completion2025-07-01
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06424314

Summary

This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline physiologic parameters of the patients prior to the spontaneous breathing test（SBT). The participants will be divided into a successful withdrawal group and a failed withdrawal group according to the SBT outcome, and the changes in the above parameters during SBT will be compared between the two groups .

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Invasive mechanical ventilation for at least 48 hours

Exclusion Criteria:

* neuromuscular disease；Postoperative patients or patients with traumatic brain injury

Conditions5

Central Respiratory DepressionDepressionDiaphragm InjuryPhrenic Nerve DisorderWeaning Failure

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