Ablation Strategies for Persistent Atrial Fibrillation Combined With Heart Failure

Summary

(1) To evaluate the efficacy and safety of "2C3L" strategy combined with VOM anhydrous ethanol chemical ablation for persistent atrial fibrillation complicated with heart failure; (2) To evaluate the effectiveness of high-efficiency ablation of atrial fibrillation complicated with heart failure.

Eligibility

Inclusion Criteria:

1. age:18y-80y
2. First ablation on non valvular atrial fibrillation
3. Persistent atrial fibrillation with LVEF≤40%
4. The patient has symptoms related to atrial fibrillation, including but not limited to palpitations, premonitory syncope, syncope, fatigue, and shortness of breath, and is evaluated for clinical cardiac function between NYHA II-IV levels
5. No response to antiarrhythmic drugs, unacceptable side effects, or unwillingness to take antiarrhythmic drugs.

Exclusion Criteria:

1. Paroxysmal atrial fibrillation
2. Atrial fibrillation secondary to obvious reversible causes
3. Echocardiography: Parasternal long axis section, left atrial diameter ≥ 60mm
4. LVEF \>40%
5. Receiving dual antithrombotic therapy
6. Contraindications to the use of oral anticoagulants
7. Contraindications to right or left cardiac catheterization
8. pregnancy
9. Life expectancy\<1 year (such as advanced malignant tumors, advanced kidney disease, etc.)
10. Unable to discontinue antiarrhythmic drugs due to reasons other than atrial fibrillation

Conditions3

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