Understanding the Variation of Modern Endoscopic Ultrasound Use in Patients with Oesophageal Cancer (VALUE)

Summary

This is an observational trial that will look at patients undergoing endoscopic ultrasound (EUS) in patients with oesophageal cancer and to determine the proportion of cases in which EUS changes disease management in these patients.

Eligibility

Inclusion Criteria:

1. Patients aged 16 or above with first diagnosis of biopsy-confirmed oesophageal cancer.
2. Referred for EUS examination as part of standard of care investigations.
3. Tumour location in the oesophagus, or gastro-oesophageal junction (Siewert types I-III)
4. MDT decision that patient is potentially curable with radical treatment (e.g., endoscopic treatment, surgery +/- neoadjuvant therapy, or definitive chemoradiotherapy)
5. Prior staging with CT and PET-CT
6. Eastern Cooperative Oncology Group (ECOG) performance status 0-2
7. Clinical staging of T1-T4, N0-N3, M0 disease
8. Adenocarcinoma or squamous cell carcinoma (SCC) histopathological cell type

   Exclusion Criteria:
9. Recurrent or residual disease
10. Distant metastatic disease detected before EUS.
11. Previous oesophagectomy or oesophageal radiotherapy
12. Unable to undergo EUS examination.
13. Concurrent malignancy e.g., second primary tumour
14. Other histopathological cell type

Conditions2

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