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Adherence to Medication in Patients With Acute Decompensated Heart Failure

RECRUITINGSponsored by Universität des Saarlandes
Actively Recruiting
SponsorUniversität des Saarlandes
Started2023-02-01
Est. completion2024-10-31
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06459115

Summary

Every day, patients present to emergency department due to acute heart failure. There are many causes for decompensation. One possible cause is a lack of adherence to heart failure medication (prognosis-improving medications and diuretics). The aim of this study is to directly measure adherence in patients with acute heart failure (gold standard of adherence measurement using liquid chromatography coupled to high-resolution mass spectrometry= LC-HRMS/MS) at the emergency department. Questionnaires are used to investigate possible factors influencing adherence.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* age ≥18 years of age
* known chronic heart failure irrespective of ejection fraction (heart failure with reduced, mildly reduced, or preserved ejection fraction)
* requirement of intravenous diuretics (outpatient or stationary treatment)
* stable heart failure medication \>2 weeks
* ≥1 sign of volume overload (peripheral edema, jugular venous distension, pulmonary rales, ascites, or demonstration of pulmonary venous congestion on chest X-ray)
* elevated natriuretic peptides (N-terminal pro brain natriuretic peptide= nt-pro-BNP ≥125 pg/ml)

Exclusion Criteria:

\- Not able to give written informed consent

Conditions2

Acute Decompensated Heart FailureHeart Disease

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