Clinical Utility of Tight Objectives of Advanced Hybrid Closed-loop Systems Among Type 1 Diabetes Patients (TightT1AHCL)

Summary

Diabetes is a chronic disease with a relevant public health burden. Maintaining blood glucose levels as close to normal as possible is essential to avoid the associated microvascular and macrovascular complications. Therefore, the key to prevent and/or reduce the development of these chronic complications lies in an adequate and strict glycemic control. This study consist of a prospective analytical clinical study in patients with type 1 diabetes (T1D). The main objective is to analyze the effect on time in range (TIR, 70-180 mg/dL) of interstitial glucose after switching to a tighter glucose objective in advanced hybrid closed-loop (AHCL) treated adult T1D patients previously treated with multiple dose insulin injection (MDI) or other AHCL systems without tighter glucose objective function.

Eligibility

Inclusion Criteria:

* Patients with type 1 diabetes.
* Age greater than or equal to 18 years.
* HbA1c \> 7% (previous poor glycemic control condition).
* Prior treatment with MDI or aHCL.

Exclusion Criteria:

* Other types of diabetes.
* Pregnancy or pre-conception control.
* Uncontrolled psychiatric disease.
* Current or previous treatment with CamAPS-Ypsopump.
* No glucometric data available during the periods under study.
* History of severe hypoglycemia.

Conditions2

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