Heart Analysis in GATED-PET in Patients Having a Gallium-68-DOTATOC PET/CT Exam for Oncology Indication

Summary

Gallium-68-DOTATOC binds primarily with high affinity to somatostatin subtype 2 (SSTR2) receptors and these somatostatin receptors are also overexpressed on inflammation cells when activated. The hypothesis is that the GATED mode on a Gallium-68-DOTATOC cardiac recording would be able to highlight abnormalities that could be correlated with the age of the patients and their cardiovascular risk factors.

Eligibility

Inclusion Criteria:

Persons who have received complete information on the organization of the research and who have signed the informed consent and:

* Age ≥ 18 years old.
* Having read and understood the information document.
* Affiliated to a social security scheme.

Person for whom a 68Ga-DOTATOC PET/CT exam is requested as part of the diagnostic or pre-therapeutic assessment of a neuroendocrine tumour.

Exclusion Criteria:

Person with

* Hypersensitivity during previous use of 68Ga-DOTATOC
* Impossibility of performing a PET-CT (patient agitated, confused, etc.).
* History of heart disease,
* Severe arrhythmia that does not allow the PET synchronized with the ECG
* Severe renal insufficiency (GFR \<30 ml/min/1.73 m2)
* Treated with a somatostatin analogue.
* Cushing's syndrome
* Pregnant woman, likely to be or breastfeeding
* Adult subject to a legal protection measure (guardianship, curators, legal safeguard)
* Person of legal age unable to express their consent
* Person deprived of liberty by a judicial or administrative decision
* Person, subject to psychiatric care under articles L. 3212-1 and L. 3213-1

Conditions2

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