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Sensitivity of Organoids to Predict Treatment Outcome in Breast Cancer Metastases

RECRUITINGSponsored by King's College London
Actively Recruiting
SponsorKing's College London
Started2025-05-27
Est. completion2026-06-30
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06468124

Summary

The aim of the study is to generate patient-derived organoids (PDOs) from brain resection or biopsied extra-cranial metastases. The preliminary data collected will be used to assess the ability of PDOs to predict patients' treatment response and their radio-sensitivity and chemo-sensitivity can be correlated with their survival outcome.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Breast cancer patients with brain metastases who are suitable for surgical resection or Breast cancer patients with extra-cranial metastases undergoing surgical resection or biopsy
* Age \> 18 years old

Exclusion Criteria:

* Patients unable to give informed consent e.g., mental disability or vulnerable adults

Conditions3

Breast CancerBreast NeoplasmsCancer

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