GDFT on the Postoperative Outcome in Head and Neck Cancer Surgery

Summary

The goal of this clinical trial is to evaluate whether goal-directed fluid therapy (GDFT) can improve the postoperative recovery in patients undergoing head and neck cancer surgery. It aims to answer is: • Whether GDFT can reduce the occurrence of serious postoperative complications? Researchers will compare GDFT protocol to a standard conventional fluid therapy in head and neck cancer surgery to see if GDFT strategy works to improve the postoperative recovery. Participants will * Receive GDFT protocol or a conventional fluid therapy during the surgery. * Be continuously follow-up during hospitalization and after discharge to record the occurrence of postoperative complications.

Eligibility

Inclusion Criteria:

* Adult patients (Age≥18)
* Scheduled to undergo head and neck cancer surgery (including nasopharyngeal carcinoma, laryngocarcinoma, hypopharyngeal carcinoma, and other head and neck malignancies, but not thyroid cancer) with an expected duration of 2 hours or longer
* Agree to receive invasive artery blood pressure monitoring

Exclusion Criteria:

* American Society of Anesthesiologists (ASA) classification\>Ⅳ
* Palliative surgery was performed for the terminal tumors
* Microlaryngoscopic laser surgery or endoscopic surgery
* Underwent major thoracic or abdominal surgery within 30 days
* Regular renal replacement therapy is required
* NYHA grade\>3 or ejection fraction \<30%
* Lung disease does not tolerate the tidal volume by 8 ml/kg
* Atrial fibrillation
* Unable to give informed consent
* pregnant or lactating woman
* Emergency surgery

Conditions2

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