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Older People's Neurocognitive Recovery After Cardiac Surgery

RECRUITINGSponsored by Karolinska Institutet
Actively Recruiting
SponsorKarolinska Institutet
Started2024-11-01
Est. completion2026-12
Eligibility
Age65 Years+
Healthy vol.Accepted

Summary

Society is aging and advantages in anesthesia and surgery allow more complex interventions in older persons. Old age is a significant risk factor for the development of postoperative neurocognitive decline characterized by a gradual decrease in performance in several cognitive domains such as memory, attention, information processing, and executive functions, leading to problems with performing daily activities and maintaining independence and postoperative complications. The purpose of this study is to measure older persons' postoperative neurocognitive function, to detect neurocognitive decline, and to identify risk factors and difficulties in daily living as well as explore close relatives' experiences of it. We will include 220 participants ≥65 years of age undergoing planned cardiac surgery. Cognitive symptoms and signs and neurocognitive function will be assessed up to 6 months after surgery. Risk/affected factors such as delirium, functional status, recovery, depression, and healthcare-related quality of life, as well as close relative's experiences and burden, will be measured. The results will have immediate relevance for a substantial number of older persons undergoing surgery, and their close relatives, by enhancing knowledge about postoperative cognitive decline and recovery, and subsequently identifying what support needs to be implemented.

Eligibility

Age: 65 Years+Healthy volunteers accepted
Inclusion Criteria:

* Scheduled for elective or urgent open-heart surgery or minimally invasive cardiac surgery
* Resident in the area/region for the current thoracic clinic
* Able to read and understand Swedish

Exclusion Criteria:

* Physical, mental, and cognitive difficulties that prevent the individual from completing the cognitive tests
* Undergone surgery within the last 6 months

Conditions4

Cardiac SurgeryHeart DiseasePostoperative Cognitive DysfunctionPostoperative Recovery

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