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Precision Medicine in Cardiovascular Surgery Associated Acute Kidney Injury

RECRUITINGSponsored by Insel Gruppe AG, University Hospital Bern
Actively Recruiting
SponsorInsel Gruppe AG, University Hospital Bern
Started2024-06-16
Est. completion2026-01-31
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06471621

Summary

The goal of this prospective observational study is to define a risk profile for cardiovascular surgery associated acute kidney injury (AKI), using clinical patient characteristics, operation parameters as well as blood and urine laboratory values. The main question it aims to answer is: • Does a combination of the factors mentioned above better predict patient outcome than classical factors used to date in clinical practice? Participants of this study are adults aged 18 and above who are scheduled for elective heart or main artery surgery, and who have given written informed consent.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Patients undergoing elective cardiovascular surgery, such as valvular replacement surgery, with or without combined coronary artery bypass graft (CABG), or thoracic or abdominal aortic surgery.
* Written informed consent obtained prior to surgery.

Exclusion Criteria:

* Patients with a kidney transplant or on renal replacement therapy
* Severe liver failure, defined by the presence of encephalopathy, Factor V \< 50% and INR \>1.5 on preoperative blood sample (within 4 weeks).

Conditions4

Acute Kidney InjuryFrailtyHeart DiseaseSurgery--Complications

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