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Inflammation and Postoperative Atrial Fibrillation in Cardiac Surgery

RECRUITINGSponsored by Odense University Hospital
Actively Recruiting
SponsorOdense University Hospital
Started2022-01-01
Est. completion2027-01-01
Eligibility
Age18 Years – 99 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06475547

Summary

Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery, marked by an irregular and rapid heart rate, and associated with increased morbidity, longer hospital stays, and higher costs. Its complex pathophysiology involves atrial remodeling, inflammation, and autonomic dysregulation. Surgical trauma and cardiopulmonary bypass trigger an inflammatory response, releasing cytokines. Epicardial fat around the heart secretes pro-inflammatory cytokines, and its increased thickness is linked to higher inflammation and atrial fibrillation. This study uses RNA sequencing (RNA-seq) to profile gene expression in epicardial fat, identifying key genes involved in inflammation and metabolism. By comparing patients with and without POAF, RNA-seq reveals differentially expressed genes associated with postoperative atrial fibrillation.

Eligibility

Age: 18 Years – 99 YearsHealthy volunteers accepted
Inclusion Criteria:

* Age \> 18
* Informed consent

Exclusion Criteria:

* Incompetent individuals
* General poor health condition at the time of inclusion
* Reoperation

Conditions3

Atrial FibrillationHeart DiseaseInflammation

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