Effects of Resistance Training in Multiple Sclerosis: a Randomized Trial.

Summary

This is a longitudinal study to examine the effects of a short-term training program on neurofilamet and GFAP plasma levels. Participants will be divided in two groups: control group (moderate aerobic training) and active group (resistance training). The change in biomarkers will be analyzed pre and post intervention in both groups. Differences between groups will be also evaluated by investigators.

Eligibility

Inclusion Criteria:

1. \- Diagnosis of multiple sclerosis according to the 2017 Mc Donald criteria (Thompson A et al).
2. \- Age \> 18 years - up to no age limit
3. \- Disability assessed by the EDSS (Expanded disability status scale) with a score less than or equal to 4.
4. \- Clinical stability. Not having had an outbreak of the disease in the last 6 months.
5. \- No changes in the disease-modifying treatment in the last 6 months or no treatment.
6. \- Radiological stability. Patients with last MRI (magnetic resonance imaging) performed without inflammatory activity (absence of new lesions on T2 sequences or lesions that enhance with gadolinium).
7. \- They must sign the informed consent

Exclusion Criteria:

1. \- Patients with a high level of physical activity according to the International Physical Activity Questionnaire(IPAQ) or latest WHO (World Health Organization) recommendations on physical activity
2. \- Pregnant or breastfeeding patients.
3. \- Concomitant pathologies that limit the performance of physical exercise

Conditions1

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