NMR Based Metabolomic Study of Serum Biomarkers in Patients With Parkinson's Disease and Atypical Parkinsonian Syndrome

Summary

At present, the diagnosis of Parkinsons disease(PD) mainly relies on clinical symptoms and is easily confused with atypical Parkinsonian syndrome(APS) in the early stages. There is an urgent need for reliable biomarkers. This project aims to use metabolomics technology based on proton nuclear magnetic resonance spectroscopy to study the metabolomic characteristics of patients with PD and APS, and preliminarily screen for possible diagnostic biomarkers of PD and APS.

Eligibility

Inclusion Criteria:

* 1\) MSA and PSP inclusion criteria

  * Age range from 45 to 80 years old;

    1. MSA inclusion criteria
  * Age range from 45 to 80 years old;

    * Meets the Chinese expert consensus on the diagnostic criteria for multiple system atrophy (2017) or the International Society for Parkinson\'s Disease and Movement Disorders (MDS) diagnostic criteria for multiple system atrophy (2022)

      ③ MSA subtype grouping: MSA is divided into MSA-P and MSA-C subtypes based on the severity of initial and/or motor symptoms, with Patients with Parkinson\'s syndrome as the main type are MSA-P, while patients with cerebellar syndrome as the main type are MSA-C.

      (2) PSP inclusion criteria
  * Age range from 45 to 80 years old;

    ② PSP patients who meet the diagnostic criteria for progressive supranuclear palsy in China (2016) or the diagnostic criteria for progressive supranuclear palsy in the International Society for Parkinson\'s Disease and Movement Disorders (MDS) (2017)

    (3) Selection criteria for Parkinson\'s disease case group
  * Age range from 45 to 80 years old;

    * Patients with idiopathic Parkinson\'s disease who meet the diagnostic criteria of the International Committee on Motor Disorders (MDS) for Parkinson\'s disease (2015);

      * Classification criteria for subtypes of Parkinson\'s disease:

        1. Tremor predominant type: According to the MDS-UPDRS score, the ratio of average tremor score to average PIGD score is ≥ 1.15
        2. PIGD type: According to the MDS-UPDRS score, the ratio of average tremor score to average PIGD score is ≤ 0.9

           Exclusion Criteria:
* ① Hereditary Parkinson\'s syndrome, secondary Parkinson\'s syndrome.

  * After deep brain stimulation (DBS) surgery.

    * Have a history of malignant tumors.

Conditions3

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