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Nausea Induced by Radiation of the Dorsal Vagal Complex for Benign Brain Tumors (NausiCAA)

RECRUITINGSponsored by University Hospital, Bordeaux
Actively Recruiting
SponsorUniversity Hospital, Bordeaux
Started2022-05-20
Est. completion2026-06
Eligibility
Age18 Years+
View on ClinicalTrials.gov →

NCT06506578

Summary

Patients irradiated to the brain frequently experience nausea. The dorsal vagal complex (DVC) area is a specific brainstem zone and has been identified as likely responsible for nausea. Existing clinical studies show correlation between dose to the DVC and nausea, but they concern tumors of the airways and upper digestive tract, where there are many confounding factors. The aim of this study is to establish a ling between radiation dose to the DVC and nausea. Defining a dose threshold to the DVC will allow radiation oncologists to optimize radiation dose distribution and reduce nausea in patients.

Eligibility

Age: 18 Years+
Inclusion Criteria:

* More than 18 years old
* With benign brain tumor
* Irradiated with conventional fractionation (1,8-2Gy/fraction)

Exclusion Criteria:

* History of brain radiation
* History of head and neck radiation
* Demencia
* Concurrent chemotherapy
* Nausea at the time of inclusion
* Anti-nausea treatment : corticosteroids, metoclopramide, setrons, other

Conditions2

Benign Brain TumorCancer

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