Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome

Summary

The goal of this case-control study is to pave the way for new revolutionary treatment measures within hearing loss that could either replace or delay the need for hearing aids. The study focuses on people with Turner syndrome (TS). The aim is to find out if there are specific DNA methylation patterns and/or RNA expression profiles linked to sensorineural hearing loss (SNHL) in people with TS. Additionally, the structure and function of the inner ear in these individuals will be examined to see if there is a connection to their epigenetic profile. The main question it aims to answer is: Does epigenetics constitute a common denominator for some of the unexplained SNHL cases? Turner Syndrome (TS) represents an ideal model for studying epigenetics related to sensorineural hearing loss (SNHL). Participants will undergo the following tests: * Ear examinations * Hearing tests * Balance tests * Blood tests * MRI scans * CBCT (cone-beam computed tomography) scans

Eligibility

Inclusion Criteria:

* age between 18 and 60 years old

Exclusion Criteria:

* Contraindications for the MRI or CBCT
* Serious medical disorders
* Neurological or psychiatric disorders of any kind
* Use of medication that is known to influence inner ear function
* Medical history with dizziness or hearing problems (controls only)

Conditions4

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