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National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry

RECRUITINGSponsored by Hospital do Coracao
Actively Recruiting
SponsorHospital do Coracao
Started2025-04-30
Est. completion2026-08-31
Eligibility
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06546137

Summary

The goal of this observational study is to develop a registry of Brazilian patients with hereditary cardiovascular diseases, combining clinical and genomic data. The main questions it aims to answer are: Which genes are most commonly affected? What is the frequency of these genetic alterations in our population? Participants will be interviewed in routine medical care visits and their DNA will be sequenced.

Eligibility

Healthy volunteers accepted
Inclusion Criteria:

* Clinical diagnosis of a hereditary cardiovascular disease according to current clinical guidelines
* Agree to receive genetic counseling
* Sign informed consent form
* Provide the information required in the case report form

Exclusion Criteria:

* Signature absent from informed consent form
* Inadequate buccal swab (sample may be collected twice)

Conditions15

Arrhythmogenic Right Ventricular DysplasiaBrugada SyndromeCardiomyopathy RestrictiveCardiomyopathy, DilatedCardiomyopathy, HypertrophicCatecholaminergic Polymorphic Ventricular TachycardiaEhlers-Danlos Syndrome, Vascular TypeFamilial HypercholesterolemiaHeart DiseaseLoeys-Dietz Syndrome

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