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Study to Understand Novel Biomarkers in Researching Dementia

RECRUITINGSponsored by Washington University School of Medicine
Actively Recruiting
SponsorWashington University School of Medicine
Started2024-08-14
Est. completion2028-12
Eligibility
Age60 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06547099

Summary

The purpose of this study is to determine the relationships between amyloid, tau, and neurodegeneration biomarkers in the blood and the presence of Alzheimer's disease (AD) pathology, clinical cognitive decline, and diagnosis. We aim to understand how well blood-based biomarkers can diagnose and predict Alzheimer's disease, which will help to further develop and validate blood tests for the disease.

Eligibility

Age: 60 Years+Healthy volunteers accepted
Inclusion Criteria:

* At least 60 years of age
* 80% of the newly enrolled clinic-based cohort will have symptoms of forgetfulness, mild cognitive impairment, mild dementia, or Alzheimer's disease as determined by their medical chart and/or provider
* All SEABIRD participants will be invited to participate regardless of their cognitive status

Exclusion Criteria:

* Unable to perform one or more basic activities of daily living (eating, bathing, dressing, ambulating, toileting) due to cognitive impairment
* Uncontrolled hepatitis B, hepatitis C, or HIV at time of blood collection
* Taking a disease-modifying drug for AD at time of enrollment
* Blood transfusion in the last three months
* Unwilling or unable to participate in all study activities

Conditions4

Alzheimer DiseaseAlzheimer's DiseaseDementiaMild Cognitive Impairment

Locations1 site

Washington University School of Medicine
St Louis, Missouri, 63110
Lisa Soke314-747-4857sunbirdstudy@wustl.edu

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