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Establish Diagnostic and Prognostic Models for Preclinical AD Patients Based on Multimodal MRI, Behavioral, Genetic, and Plasma Biomarkers

RECRUITINGSponsored by The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Actively Recruiting
SponsorThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Started2020-09-01
Est. completion2027-07
Eligibility
Age50 Years – 79 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06561906

Summary

To establish the diagnostic and prognostic models that could help the preclinical identification of subjects at higher risk of clinical progression to mild cognitive impairment and dementia based on combined features of baseline demographic, cognitive, behavioral, multimodal MRI, genetic, and plasma data.

Eligibility

Age: 50 Years – 79 YearsHealthy volunteers accepted
Inclusion Criteria:

* The inclusion criteria were 50-79 years old and having 8 or more years of education.

Exclusion Criteria:

* Participants with a history of stroke, other neurological disorders that could lead to cognitive impairment (Parkinson's disease, encephalitis, epilepsy, brain tumors, etc.), severe anxiety or depression, and contraindications for magnetic resonance imaging (MRI) were not enrolled.

Conditions4

Alzheimer Disease, Late OnsetAlzheimer's DiseaseMild Cognitive ImpairmentSubjective Cognitive Decline

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