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Effects of Neoadjuvant Therapy With Carboplatin, Paclitaxel Combined With Anti-PD-1 Drugs on Cognitive Function in Patients With Resectable Head and Neck Squamous Cell Carcinoma

RECRUITINGSponsored by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Actively Recruiting
SponsorSun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Started2024-08-23
Est. completion2024-09-01
Eligibility
Age18 Years – 80 Years
View on ClinicalTrials.gov →

NCT06576180

Summary

The goal of this observational study is to learn about the Effects of neoadjuvant therapy with carboplatin, paclitaxel combined with anti-PD-1 drugs on cognitive function in patients with resectable head and neck squamous cell carcinoma: a prospective cohort study

Eligibility

Age: 18 Years – 80 Years
Inclusion Criteria:

* 1: The patient was diagnosed with head and neck squamous cell carcinoma (stage I-IVA), without treatment, and planned to undergo only surgical treatment or surgical treatment + chemotherapy and immunotherapy.

  2: Can speak Chinese and have certain reading and writing skills

  3: Healthy group: Dental inpatients with non-oral cancer, no history of neurological diseases, and no previous history of malignant tumors

Exclusion Criteria:

* 1: Brain tumor, brain injury, or stroke at baseline or during follow-up

  2: A history of stroke or a medical condition that puts you at high risk for future dementia or recurrence

  3: Active mental illness or active narcotic drug use, including using alcohol more than 4 times per day or more than 4 times per week

  4: Neurocognitive diseases that affect cognitive function, such as Parkinson's disease or Alzheimer's disease

  5: History of drug-associated encephalopathy or brain infection

  6: Patients who change their treatment plan during treatment

  7: Patients who are currently taking or have taken antidepressants

Conditions2

CancerHead and Neck Squamous Cell Carcinoma

Interventions3

Anti-PD-1 DrugsCarboplatin（ neoadjuvant）Paclitaxel （neoadjuvant）

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