[18F]-rhPSMA PET-CT Imaging Performance in Patients With Prostate Cancer
NCT06580015
Summary
This clinical trial evaluates \[18F\]-rh PSMA positron emission tomography (PET)-computed tomography (CT) imaging performance in patients with prostate cancer. PET is an established imaging technique that utilizes small amounts of radioactivity attached to very minimal amounts of tracer, in the case of this research, 18F-rhPSMA. Because some cancers take up \[18F\]-rhPSMA, cancer cells can be seen with PET. CT utilizes x-rays that traverse body from the outside. CT images provide an exact outline of organs and potential inflammatory tissue where it occurs in patient's body. Posluma (18F-rhPSMA) is an approved prostate-specific membrane antigen (PSMA) imaging agent for prostate cancer. The RefleXion Medical Radiotherapy System (RMRS) is designed to facilitate delivery of biology-guided radiotherapy (BgRT). The system uses PET emissions to guide radiotherapy delivery in real-time and has been studied for use with fludeoxyglucose (FDG) (which is an agent used in standard PET-CT scans that targets glucose). Information gathered from this study may help researchers to improve PET-CT imaging on the RefleXion system. This information will be used in the future to improve planning and delivery of radiation therapy that will target (in real time) the signal released from the \[18F\]-rhPSMA PET-CT tracer. Comparing the imaging from the standard of care \[18F\]-rh PSMA PET-CT with the imaging from RMRS may help improve the quality of the imaging captured on the RMRS for detection of imaging signals in patients with prostate cancer.
Eligibility
Inclusion Criteria: * Documented informed consent of the participant and/or legally authorized representative * Age: ≥ 21 years * Patients with SOC \[18F\]-RhPSMA PET-CT in whom a PET avid lesion is identified * Able to get same day X1 RMRS PET Exclusion Criteria: * Known psychiatric or substance abuse disorder that would interfere with conduct of the study * Patient weight exceeding the weight limit (450 pounds) outlined per X1 RMRS specifications sheet
Conditions2
Locations1 site
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NCT06580015