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Precision Medicine in Alzheimer's Disease : Integration of Resilience Metrics and Risk Factors - Validation Cohort BioCogBank-AD

RECRUITINGN/ASponsored by Assistance Publique - Hôpitaux de Paris
Actively Recruiting
PhaseN/A
SponsorAssistance Publique - Hôpitaux de Paris
Started2024-10-31
Est. completion2027-09
Eligibility
Age50 Years – 90 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06582199

Summary

BioCogBankAD aims at building a prospective clinical practice cohort of 244 patients with biologically confirmed mild cognitive impairment due to Alzheimer's Disease (AD) or mild AD in order to validate data regarding markers of resilience toward AD pathophysiological process discovered in an upstream project called AD-Resilience.

Eligibility

Age: 50 Years – 90 YearsHealthy volunteers accepted
Inclusion Criteria:

* Diagnosis of AD according to IWG-2 2014 criteria
* Age 50-90 year old
* Affiliated or beneficiary of a social security scheme
* MMSE ≥ 20
* Abnormal CSF Aβ42 or Aβ40/Aβ42 ratio according to local cut-offs
* Abnormal CSF phosphorylated and total Tau according to local cut-offs
* Ability to pass neuropsychological assessments
* Availability of a brain MRI with T1 volumetric sequence performed within 1 year

Exclusion Criteria:

* Other cause of dementia
* Participation in an AD therapeutic clinical trial
* Protected adults (including individual under guardianship by court order),

Conditions2

Alzheimer DiseaseAlzheimer's Disease

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