Cardiac Radioablation for VT

Summary

The goal of this interventional study is to determine the minimum dose necessary for successful cardiac radioablation of refractory ventricular tachycardia (VT) and to study the utility of target volume definition using Delayed Enhancement Cardiac MRI (DE-CMR) .

Eligibility

Inclusion Criteria:

* Participants must be 18 years or older.
* Automatic implanted cardiac defibrillator present.
* VT is monomorphic with at least two episodes of VT within an eight week (56 day) period as recorded by an AICD or heart failure related to VT or VT storm.
* Ejection fraction ≥20%.
* At least one previous cardiac ablation for VT.
* VT refractory despite antiarrhythmic medications.
* Likely to live for 12 months in the absence of VT.
* AICD in a position in the chest RT to be given without direct radiation.
* Woman of reproductive age must ensure that she won't become pregnant or breastfeed at the time of RT.
* The participant has no contraindications to a Cardiac MRI as per routine Cardiology practice.

Exclusion Criteria:

* Class IV heart failure
* Abandoned leads.
* Prior radiation therapy to the chest or upper abdomen.
* Interstitial lung disease.

Conditions3

Locations1 site

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