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Investigating the Impact of Duration and Amount of Light on the Circadian System Response - Aim 3

RECRUITINGN/ASponsored by Icahn School of Medicine at Mount Sinai
Actively Recruiting
PhaseN/A
SponsorIcahn School of Medicine at Mount Sinai
Started2024-12-03
Est. completion2026-12-31
Eligibility
Age55 Years+
Healthy vol.Accepted
Locations2 sites
View on ClinicalTrials.gov →

NCT06595030

Summary

Investigate the long-term impact of amount and duration of Tailored Lighting Intervention (TLI) obtained from Aims 1 and 2 on sleep, cognition, circadian marker, mood, and behavior in AD/ADRD patients. For this single-arm, randomized, placebo-controlled study, the researchers plan to recruit 100 participants who will experience either the active TLI or the placebo for 6 months.

Eligibility

Age: 55 Years+Healthy volunteers accepted
Inclusion Criteria:

* Diagnosis of Alzheimer's disease or related dementia with a Montreal Cognitive Assessment score \<25
* Sleep disturbance with a Pittsburgh Sleep Quality Index score ≥5

Exclusion Criteria:

* Extensive brain vascular disease, traumatic brain injury, multiple sclerosis, Parkinson's Disease
* Obstructing cataracts
* Severe macular degeneration
* Use of sleep medication
* Use of oral melatonin
* untreated moderate to severe sleep apnea
* Severe restless leg syndrome - Blindness

Conditions2

Alzheimer's DiseaseMild Cognitive Impairment

Locations2 sites

Icahn School of Medicine at Mount Sinai
Menands, New York, 12204
Barbara Plitnick518-242-4603barbara.plitnick@mountsinai.org
Icahn School of Medicine at Mount Sinai
New York, New York, 10029
Barbara Plitnick518-242-4603barbara.plitnick@mountsinai.org

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