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Loss of Y Chromosome in Aortic Stenosis

RECRUITINGSponsored by University of Virginia
Actively Recruiting
SponsorUniversity of Virginia
Started2024-08-15
Est. completion2025-12-31
Eligibility
Age40 Years+
SexMALE
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT06595407

Summary

The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure and need for valve replacement procedures (including surgery and catheter-based replacement). Aortic stenosis has a strong male predominance. The purpose of this study is to evaluate whether loss of Y-chromosome from circulating blood cells in males, which has been associated with TGF-beta-related fibrosis of other organs, is associated with the development of aortic stenosis.

Eligibility

Age: 40 Years+Sex: MALEHealthy volunteers accepted
Inclusion Criteria:

* Aortic stenosis (valve area \<1.5cm2)

Exclusion Criteria:

* Bicuspid aortic valve
* History of radiation to chest
* Inflammatory (autoimmune, rheumatologic) disease associated with aortic stenosis
* Active cancer

Conditions2

Aortic StenosisHeart Disease

Locations1 site

University of Virginia
Charlottesville, Virginia, 22903
Jonathan Lindner503-260-0672jlindner@virginia.edu

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