Functional Outcomes in CondUction System Pacing and Right Ventricular Synchrony (FOCUS-Right)
NCT06601322
Summary
The goal of this prospective single center clinical trial is to evaluate the safety and feasibility of performing simultaneous exercise stress cardiac magnetic resonance (CPET-CMR) and cardiopulmonary exercise testing in patients with pre-existing left bundle branch area pacemakers (LBBAP) programmed to an atrial sensing mode. Measurements of right ventricular, left ventricular function, and exercise capacity will be obtained at various LBBAP programming parameters at rest and during low intensity exercise. The main aims of the study are: * Demonstrate the safety and feasibility of performing CPET-CMR in patients with pre-existing LBBAP programmed to P-synchronous ventricular pacing mode. * Generate preliminary data evaluating differences in RV function, LV function, and exercise capacity during various pacemaker programming settings.
Eligibility
Inclusion Criteria: * presence of dual chamber LBBAP implantation * presence of anodal capture with bipolar pacing configuration as determined at pacing implant. Exclusion Criteria: * Known history of chronotropic incompetence * high degree or complete heart block * inability to tolerate NVP during initial device interrogation * pregnancy * inability to undergo MRI or exercise utilizing supine bicycle at target work-load * presence of MRI unsafe pacemaker components.
Conditions3
Locations1 site
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NCT06601322