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Understanding the Transition from Normal Melanocytes to Nevus to Melanoma

RECRUITINGSponsored by Fundacion Clinic per a la Recerca Biomédica
Actively Recruiting
SponsorFundacion Clinic per a la Recerca Biomédica
Started2024-01-01
Est. completion2026-03-31
Eligibility
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06605417

Summary

The primary objective of this study is to identify the molecular identity profiles of all cellular states that characterize the progression from benign nevi to malignant melanoma in CAYA patients with L/GCMN. The secondary objectives are: * To longitudinally characterize the cell-free DNA (cfDNA) from CAYA patients. * To improve the early diagnosis and treatments for intermediate conditions such as L/GCMN through evidence-based interpretation of personal risk from endogenous or exogenous sources. * To test pre-clinical strategies to best model and improve patient response.

Eligibility

Healthy volunteers accepted
Inclusion criteria:

* Congenital nevus with estimated size of 20 cm
* Be over 18 years of age

Exclusion criteria:

* No available biological material
* Not having signed the informed consent

Conditions4

CancerCongenital Melanocytic NeviMelanoma (Skin)Nevi and Melanomas

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