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Intravenous Acetaminophen After Cardiac Surgery - Definitive Study

RECRUITINGPhase 4Sponsored by McGill University Health Centre/Research Institute of the McGill University Health Centre
Actively Recruiting
PhasePhase 4
SponsorMcGill University Health Centre/Research Institute of the McGill University Health Centre
Started2024-07-02
Est. completion2027-07-01
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06613178

Summary

Double blind, double dummy trial of the use of IV acetaminophen versus oral acetaminophen for the prevention of delirium after cardiac surgery. The underlying hypothesis is that better pain control and less use of narcotics will lead to a lower incidence of delirium from day 1 to 7 following cardiac surgery. Other important secondary outcomes are the total use of narcotics, ICU and hospital stay, improved cognitive function at 6 months and 1 year post surgery, NSAID use at each centre and associated NSAID complications.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

greater or equal to 18

* elective cardiac surgery
* stable pre-operative
* aorto-coronary bypass with or without 1 valve replacement.

Exclusion Criteria:

Refusal by surgeon Requested late extubation by surgeon or anesthesia Intra-aortic balloon pump Mechanical cardiac support Sensitivity to acetaminophen Psychiatric history with current active treatment Alzheimer\'s disease Seizure in previous 6 months Recent history of alcohol misuse Cognitive impairment

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Conditions5

Heart DiseasePost Operative PainPost-Op ComplicationPost-cardiac SurgeryPost-operative Delirium

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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