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Study of Thoracic Ultrasound As a Response to the Closure of Hemodynamically Significant Patent Ductus Arteriosus in Premature Infants

RECRUITINGSponsored by Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Actively Recruiting
SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS
Started2024-09-20
Est. completion2026-09-30
Eligibility
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06627374

Summary

The diagnostic hypothesis is based on the evidence that, while the functional closure of the PDA (Patent Ductus Arteriosus) occurs within a few hours after birth, anatomical closure may take several weeks. The functional closure of the PDA can be extremely sensitive to variations in blood oxygen tension and the hemodynamic instability of preterm infants. Therefore, echocardiographic evaluation and ductal diameter at a single point in time (such as during PDA echocardiography) may not correlate with transductal blood flow. Assessing the variation in the amount of pulmonary interstitial fluid using LUS (lung ultrasound score) could be an early predictive parameter for the closure or non-closure of hsPDA (hemodynamically significant PDA).

Eligibility

Healthy volunteers accepted
Inclusion Criteria:

* Neonates under 28 days of life
* Patients eligible for hsPDA closure treatment according to standard clinical practice

Exclusion Criteria:

* Neonates with congenital heart diseases (except for PDA and patent foramen ovale)
* Neonates with pneumothorax
* Neonates with pulmonary hemorrhage

Conditions2

Heart DiseasePatency of the Ductus Arteriosus

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