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Screening Strategies Among High-risk Populations for Anal Cancer

RECRUITINGN/ASponsored by Lisa Flowers
Actively Recruiting
PhaseN/A
SponsorLisa Flowers
Started2024-12-16
Est. completion2027-10
Eligibility
Age30 Years – 80 Years
Healthy vol.Accepted
Locations4 sites
View on ClinicalTrials.gov →

NCT06628570

Summary

The goal of the proposed research is to 1) examine the performance of emerging screening methods for anal high-grade squamous intraepithelial lesion (aHSIL), a precancerous condition of anal cancer, among populations at high risk for anal cancer and 2) characterize DNA methylation, immunologic response, and environmental factors associated with aHSIL.

Eligibility

Age: 30 Years – 80 YearsHealthy volunteers accepted
Inclusion Criteria:

* 30-80 years of age
* Individuals with chronic impaired immune status
* History of high-grade lower genital tract neoplasia (LGTN), Zubrod Performance Status of 0-2;

Exclusion Criteria:

* Patients treated for aHSIL less than 6 months before screening,
* History of anal cancer and pregnant women.

Conditions3

CancerHPV-Related Anal Squamous Cell CarcinomaNeoplasms

Locations4 sites

Florida

2 sites
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136
Isabella Rosa-Cunah, MD
University of Miami School of Medicine at Jackson Memorial Hospital (JMH)
Miami, Florida, 33136
Isabella Rosa-Cunha, MD

Georgia

2 sites
Grady Memorial Hospital
Atlanta, Georgia, 30303
The Ponce Center
Atlanta, Georgia, 30308
Lisa Flowers, MD404-778-1380lflowe2@emory.edu

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