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Personalized ViscoElastic Testing-guided Bleeding Management In Liver Surgery, Neurosurgery and Obstetrics

RECRUITINGSponsored by Medical University of Vienna
Actively Recruiting
SponsorMedical University of Vienna
Started2024-07-01
Est. completion2026-04-30
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06635564

Summary

The ClotPro analyzer is a new generation viscoelastic analyzer for the in vitro assessment of blood coagulation. This study aims to assess the agreement of ClotPro 6.0, ROTEM delta, and TEG 6s in three distinct cohorts: i) patients with liver disease undergoing liver surgery, ii) pregnant women undergoing elective cesarean section, and iii) patients undergoing elective intracranial neurosurgery. Further coagulation tests will be performed (standard laboratory coagulation tests, thrombin and plasmin generation tests) in an exploratory fashion to compare them with viscoelastic test results. The obtained test results will not result in any diagnostic or therapeutic consequences for patients included in this study.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

1. Vulnerable patient cohorts

   * Patients undergoing elective liver surgery defined as one of the following invasive procedures:

     * Liver resection (anatomic or non-anatomic segmental resection, right or left hepatectomy, right or left extended hepatectomy),
     * Orthotopic liver transplantation,
   * Pregnant women undergoing an elective caesarean section, and
   * Patients undergoing an elective intracranial neurosurgery.
2. Written informed consent

Exclusion Criteria:

none

Conditions6

Bleeding DisorderIntracranial HemorrhagesLiver DiseaseLiver TransplantPostpartum HemorrhageThrombelastography

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