Electrophysiological Signature of Mild Cognitive Impairment and Its Relationship with Parkinson's Disease: a High-density EEG Investigation

Summary

The study aims to investigate neural correlate of Mild Cognitive Impairment (MCI) in Parkinson's disease (PD) and to identify a link between functional impairment (in both cognitive and motor domains) and electrophysiological cortical sing of MCI in PD. A sample of 42 subjects will be divide into three subgroup: healthy control, PD with MCI (PD-MCI) and PD without MCI (PD-ctrl). Those subjects will undergo a specific neuropsychological evaluation and, to measure the electro-cortical activity, high-density electroencephalography (hdEEG) will be record during both resting state and cognitive tasks. Furthermore, hdEEG data will be combine with structural magnetic resonance to obtain information about network connectivity.

Eligibility

Inclusion Criteria:

* Upper score \>24 MMSE or \>15.5 Moca
* If taking medications, taking stable doses for at least 4 weeks prior to the inclusion visit - of anticholinesterase drugs (donepezil, memantine, rivastigmine, ...) or antidepressants (SSRIs, tricyclics, SNARI, ...) or Levodopa.
* Having signed the informed consent

Exclusion Criteria:

* Subjects with severe dementia ( MMSE \< 24 )
* Lower score \<15.5 Moca
* Subjects on antipsychotic treatment for less than 3 months
* Subjects with uncontrolled comorbidities
* Subjects with metal prostheses or dentures and in general conditions for which MRI examinations are prevented.
* Subjects with an inability to walk independently.

Conditions4

Browse More Trials